Abstract
A method is described for the quantitative assay of pipecolic acid in biological fluids using column chromatography, with acid ninhydrin for color development. The technique permits measurement of plasma pipecolic acid in normal individuals with blood samples of 1 ml. The mean value in 29 pediatrie patients, aged 4 months to 17 years, hospitalized with a variety of diagnoses was 2.1 μmol/l ± 1.6. Newborn infants had slightly elevated plasma levels with a mean of 12 μmol/l ±5.6. Among the diagnostic categories, patients with liver disease were distinctive in commonly having levels at the upper limits of normal. In some cases, the levels were exceedingly high, reaching 78 μmol/l in one fatal case.
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