Abstract
The powdered tablet is treated with a solution of phenol and chloroform, the tablet excipients are removed by filtration and the filtrate, after dilution with acetonitrile, is titrated potentiometrically for its codeine phosphate content with perchloric acid in p-dioxane. A standard deviation of ±0.64 per cent was obtained for five consecutive determinations using synthetic mixtures containing approximately 32 mg. of codeine phosphate. The method, therefore, can be considered to be as accurate as conventional acid-base titrations. Seven of the nineteen commercial preparations analyzed by this method contained substances which interfered in the titration of the alkaloidal salt. These tablets were assayed by suspending the powdered sample in water, adding dilute alkali, and extracting the codeine with chloroform. The volume of the chloroform solution was decreased to about 10 ml. by heating on a water bath and, after dilution with acetonitrile, the codeine content was determined potentiometric titration.
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