The determination of breast cancer risk factors: A single centre experience

Abstract

Aim: In developing countries like our country, the frequency of breast cancer is gradually increasing. There are several risk factors of breast cancer. Besides that there can be some unrevealed risk factors. The aim of our study is to reveal demographic data of patients with breast cancer followed up in our hospital and the risk factors of breast cancer.
 Material and Methods: 237 female patients treated with the diagnosis of breast cancer between 2005 and 2015 were included in the study. Demographic information, familial features, type of breast cancer, histology, stage-grade, hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status of the patients were recorded from the files of the patients.The patients diagnosed with breast cancer were grouped in terms of risk factors, prognostic factors, and the characteristics of breast cancer. 
 Results: A significant correlation was detected between early menarche and PR+ (p=0.034). It was observed that the disease occurred earlier in patients with early menarche (p=0.004). A high positive correlation was detected between TNBC and tumor size (p=0.019 r=0.581). Breast cancer was occuring in early ages in nulliparous patients and there was a moderate positive correlation between them (p=0.024 r=0.284). 
 Conclusions: We revealed that breast cancer might occur in early ages in females with early menarche or both with early menarche and nulliparity. Understanding the etiopathogenesis of this common disease is necessary to determine the content of early diagnosis, treatment, and screening programs. Each society should have their unique screening programmes as distinct from Western societies.