The determination of beta-substituted glutarimides in blood: time-concentration curves after intravenous administration of two barbiturate antagonists.

Abstract

Abstract A simple and rapid spectrophotometric procedure has been developed which is capable of estimating 2 mg. per cent of β-substituted glutarimides in blood with an accuracy of 90 per cent. Within 10 minutes of intravenous administration in guinea pigs 90 per cent of two barbiturate antagonists, β-methyl-β-ethyl glutarimide and β-spirocyclo-pentane glutarimide were removed from blood. Some discussion follows on whether the compounds were rapidly metabolised in blood or distributed evenly throughout the body tissues. The phase of rapid removal is followed by a period of moderately slow removal, apparently due to excretion.