Abstract
In this study, it was aimed to obtain the anticancer potential, pharmacokinetic and toxicity profiles of the cis-[Pt(oro)(NH3)2]. The structural parameters of the compound were determined. The effects of solvent environments were also investigated on the molecule because they are an important factor that should be taken into account in drug research processes. Pharmacokinetic and toxicity parameters of the molecule were obtained by using in silico predictions, which are good preliminary for in vitro and in vivo studies. The drug absorption, distribution, metabolism, and excretion parameters of cis-[Pt(oro)(NH3)2] were compared with those of the anticancer drug cisplatin. Molecular docking studies on oncogenes were conducted to define the anticancer potential of the molecule. The obtained ADME results showed that the title molecule’s toxicity is significantly lower than cisplatin. Molecular docking studies have revealed that the molecule docks well with the oncogene and thus may be a promising potential anticancer agent.
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