Abstract
Summary Addition of sodium nitroprusside (SNP) to a solution of sulphide at a pH above 12 produces a red-purple colour with maximum absorbance at 540nm. This colour reaction was used for the assay of SNP solutions (2040mgl-1) and to investigate changes in SNP concentration during storage. Protected from light undiluted injection solutions (10g SNP 1-1) were stable for more than two years. Foil-wrapped infusion solutions (ca. 200 mg SNP 1 -1) in 0.9% saline or 5% dextrose were stable for at least seven days, but on exposure to light the SNP concentration fell whilst the free cyanide content rose exponentially until the solutions turned blue. A 45% decrease in SNP concentration and an HCN concentration of 6mgl-resulted from 2h exposure to sunlight. Infusion solutions are best prepared in 5% dextrose and if used in direct daylight, or in diffuse daylight and/or artificial light for longer than 3 h, should be foil wrapped.
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