Abstract
Over the last two decades, it has been well clarified that the serrated/methylated pathway of colorectal carcinogenesis is responsible for about 20 %–30 % of all colorectal cancers (CRCs) and is distinct from the traditional adenoma–carcinoma sequence [1]. Three main subgroups of serrated polyps have been recognized, with different malignant potential [2]. Hyperplastic polyps (HPPs) are believed to have a benign course, unless larger than 10 mm, whereas sessile serrated lesions (SSLs), especially those with dysplasia, and traditional serrated adenomas (TSAs), regardless of their size, have the potential for malignant transformation. Therefore, there is no doubt that these precancerous lesions are clinically relevant and deserve all our attention, above all they are often flat in appearance with indistinct borders and difficult to detect.
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