Abstract
A qualitative test for thiacetazone in urine is described. The method depends on the diazotisation of the aromatic amine liberated by hydrolysis with subsequent coupling of the diazonium compound to give a characteristic dye. The test detects the drug in urine samples collected up to at least 24 hours after 100 mg. dose and from 36 to 40 hours after doses of 150 mg. and 200 mg. Since p-aminosalicylic acid gives positive results with the test, it cannot be used to detect thiacetazone if the drugs are being used together but the ferric chloride test for p-aminosalicylic acid can be applied in this case. Isoniazid does not interfere with the reaction. When the two drugs are combined in treatment, the test can be used as an alternative or in conjunction with the tests used for isoniazid.
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