Abstract
The detection of colorectal adenoma is determined by the level of plasma mSEPT9
Highlights
Colorectal cancer (CRC) is the third most common cancer in the world [1]
Our observation strongly suggests that the plasma level of methylated SEPT9 (mSEPT9) is an indicator for disease severity and detection sensitivity, and the assay itself is effective in adenoma detection
We first investigated the sensitivity of the mSEPT9 assay in normal subjects, and patients with hyperplastic polyps (HP), adenoma and CRC
Summary
Colorectal cancer (CRC) is the third most common cancer in the world [1]. Screening of CRC can reduce mortality and prolong the survival time. Current CRC screening methods, such as fecal immunochemical test (FIT), FIT-DNA test or the mSEPT9 DNA test, were designed to detect early-stage CRC and can detect some precancerous lesions as well. Detection of CRC reduces mortality while detection of precancerous lesions can reduce incidence. Screening aiming at precancerous lesions has great potential in cancer prevention. Detection of precancerous lesions in screening using current methods is accompanied by high false positive rate in other colorectal diseases and normal subjects, which hinders the use of screening methods, and further confirmatory diagnosis, such as colonoscopy, is still required. Detection of colorectal adenoma plays crucial roles in CRC early prevention and intervention. Current detection by colonoscopy is not suitable for mass screening due to its high costs and low compliance. Its ability in detecting adenoma has not been fully examined
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
