Abstract
Cell entry of the SARS-CoV-2 has been suggested to involve binding of the head domain from spike protein on the virus with hACE2 protein on the human cells. The spike protein is composed of the S1 head, S2 domain which carries two heptad repeats (HR1 and HR2) and other domains; some of which are located between the HR1 and HR2. It is believed that the S1 head is cleaved upon binding to the hACE2 receptor, which liberates a fusion peptide in the spike protein that fuses with the cell membrane of the human cell.
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