Abstract
The production rate in a crystallizer depends on the reactant feed rates or solvent evaporation rate. The product crystal size is decided from the nucleation rate, growth rate and crystal retention time. The nucleation and growth rates are affected by many operational factors, especially the supersaturation which is decided by the removal rate of solution and the reaction and crystallization rates. The crystallization rate is divided into two independent parts (the nucleation and growth rates) that are correlated independently against supersaturation. However, super-saturation is frequently difficult to measure, so nucleation rate is sometimes correlated against growth rate directly.
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