The design and synthesis of a novel chiral 1,1′-disubsitituted ruthenocenyl phosphine–oxazoline ligand

Abstract

Chiral ferrocene-based phosphine–oxazoline ligands have shown efficient asymmetric catalytic behaviors in asymmetric catalysis; however, the design and synthesis of the corresponding chiral ruthenocenes have not been widely explored. In this article, we report the synthesis of a chiral ruthenocene-based 1,1′-phosphine–oxazoline ligand, based on careful design and experimental exploration. The experimental results here reveal again that the synthetic preparation of 1,1′-disubstituted chiral ruthenocenyl ligands differs from the corresponding ferrocenes. The current method provides a feasible and practical strategy for the synthesis of 1,1′-disubstituted ruthenocene-based ligands.