Abstract
In an attempt to elucidate the relationship between depression and pain, the authors studied 300 pain center patients; 261 (87%) of these patients referred for diagnosis and treatment of their pain syndromes were depressed. In another study of 196 private patients with depression, 116 (59%) also had recurring benign pain. When treated with antidepressant medications, 96 of these 116 (83%) obtained significant relief of their pain syndromes. The frequency with which antidepressants can significantly alleviate pain associated with depression highlights the importance of the link between pain and depression, which may be partially explained by the close relationship of enkephalins and biogenic amines
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