Abstract
Nude (athymic) mice and their immune competent Balb/c litter mates were infected with herpes simplex virus (HSV) type I on the scarified cornea. Seven to eight days after infection the trigeminal root entry zone was examined by light and electron microscopy. The immune competent Balb/c litter mates demonstrated marked central nervous system (CNS) demyelination when compared to the T cell-deficient animals who showed mild edematous change and minimal CNS demyelination ultrastructurally 7 days after infection. Viral titers were similar in both groups at this time. These studies further substantiate a role for the cell-mediated immune system in the CNS demyelination 1 week after corneal infection with HSV.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
