Abstract
The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88–1.40, p = 0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy (0.14, p = 1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.
Highlights
Rapid eye movement (REM) sleep behavior disorder (RBD) is currently the strongest clinical prodromal feature preceding the development of an overt synucleinopathy, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB) or multiple system atrophy (MSA) (Iranzo et al, 2014)
Since both RBD and the APOE ε4 allele are possibly associated with DLB, and with dementia in PD patients, we aimed to examine whether the APOE ε4 allele is associated with RBD and conversion to DLB
RBD is a strong risk factor for developing DLB and DLB was reported to be associated with the APOE ε4 allele, our results demonstrate lack of association between the APOE ε4 allele and RBD or its AAO
Summary
Rapid eye movement (REM) sleep behavior disorder (RBD) is currently the strongest clinical prodromal feature preceding the development of an overt synucleinopathy, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB) or multiple system atrophy (MSA) (Iranzo et al, 2014). One of the strongest genetic factors associated with DLB is the APOE epsilon (ε4) allele (Pickering-Brown et al, 1994), and PD patients who carry this allele may be at increased risk for developing dementia. Since both RBD and the APOE ε4 allele are possibly associated with DLB, and with dementia in PD patients, we aimed to examine whether the APOE ε4 allele is associated with RBD and conversion to DLB. See Supplementary Material for detailed introduction and full list of references
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