Abstract
The increased sensitivity in neonates to the effects of certain chemicals is attributable to the immaturity of detoxifying and excretory processes as well as to the interference of the chemical with postnatal development. An adverse effect of a chemical may appear in adulthood, even though it was induced in the postnatal period, because of the late development of the function affected, e.g. reproduction or slowly progressing pathological changes. Examples of neonatally acquired effects that have been transmitted to the next generation are presented. Adaptation of the protocol for reproduction toxicology studies is suggested for the detection of these delayed and persistent toxic effects.
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