Abstract
Background: One of the problems with burn patients is the impairment of host immunity, which makes difficult to treat. In burns, immunoglobulinA has demonstrated to decrease. Immunoglobulin A is the main product of mucous immune system, which increases viral clearance and decreasesbacterial adhesion in the intestine. Probiotics consist of living microflora, which control the balance of lactobacilli and bifidobacteria in the intestine.Instead of producing organic component, increasing the acidity of intestine, mucin and bacteriocin, they also activate the intestinal immune systemand secretory immunoglobulin A (sIgA). The goal of this study was to propose that regular intake of probiotic might help to improve the mucousimmune system, especially sIgA in intestines in burn patients.Methods: An experimental, double-blind, controlled clinical trial was carried out in 33 burn patients. Those patients were divided into two groups.The first group was given daily probiotic and the second group was given only placebo for 10 days. The treatment began on the 4th day admission, andthen, the degree of sIgA was evaluated before treatment and day 14 from fecal specimen.Results: Significant differences between probiotic and control group were observed (p<0.0001). The degree of sIgA in the probiotic group increased61.25%, and in the control group, it decreased to 36.80%.Conclusion: The mucous immune system, especially sIgA, increases by probiotic intake.
Highlights
IntroductionBurns will activate a local inflammatory reaction that develops into a systemic reaction by releasing toxins associated with immunologic processes of the body, as a lipoprotein complex (lipid–protein complex, burn toxin) which induces the Systemic Inflammatory Response Syndrome (SIRS) event
Burns will activate a local inflammatory reaction that develops into a systemic reaction by releasing toxins associated with immunologic processes of the body, as a lipoprotein complex which induces the Systemic Inflammatory Response Syndrome (SIRS) event
The degree of secretory immunoglobulin A (sIgA) in the probiotic group increased 61.25%, and in the control group, it decreased to 36.80%
Summary
Burns will activate a local inflammatory reaction that develops into a systemic reaction by releasing toxins associated with immunologic processes of the body, as a lipoprotein complex (lipid–protein complex, burn toxin) which induces the Systemic Inflammatory Response Syndrome (SIRS) event. Some previous studies have noted that the incidence of bacteremia in burns patients is about to occur on the 6th to the 10th day after trauma [1,2]. Immunoglobulin A is the main product of mucous immune system, which increases viral clearance and decreases bacterial adhesion in the intestine. Instead of producing organic component, increasing the acidity of intestine, mucin and bacteriocin, they activate the intestinal immune system and secretory immunoglobulin A (sIgA). The goal of this study was to propose that regular intake of probiotic might help to improve the mucous immune system, especially sIgA in intestines in burn patients
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