Abstract
Objective To investigate the degradation, osteoacusis, induction and biocompatibility of the Hydroxyapatite ( HAP) coating magnesium alloy by implant them in rabbits' comdyles of femur. Methods 33 rabbits were devided into 3 groups: they were implanted in material without coating and material with coating respectively, and didin' t implant anything as control group. Observing the variation of serum magnesium through serology test to study the side effect of these materials. Observing degradation and newly formed bone through radiology observation; to study the time and process of degradation and the variation of surounding tissue and skeletal through histopathology test, to evaluate the biocompatibility of these materials through biology observation. Results The serum magnesium didn' t rise after implanting these materials, there were no significant difference compared with contral group (P > 0.05). The radiology result showed that materials with HAP coating degraded slowly and there were new bone formed surroud-ing it while the marerials without HAP coating degraded quickly and maby there were inflammation surround it because of the irregular osseous tissue. The histopathology result showed that there were granulation tissue and new bone trabecula formed surrounding the HAP coating materials and no severe granulation swelling and inflammatory reaction found; there were obvious granulation swelling and lymphocyte reaction exist accompanied with granulation tissue and new bone trabecula. Conclusion HAP coating magnesium alloy wouldn' t rise the magnesium in serum; the degrade velocity was variated effectively by coating with HAP; It also can accelerate the heal of osseous tissue because of its osteoacusis and entrainment. Key words: Magnesium alloy; Hydroxyapatite; Biocompatibility; Degradation
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