Abstract
Through tests on tablets made in our own laboratories and on market samples, it was noted that many formulations of aspirin, phenacetin, and caffeine showed decomposition of aspirin. The decomposition was found to be accelerated by heat. Discussion with experienced tablet formulators revealed divergent opinions as to causes of aspirin decomposition. A series of preliminary experiments indicated that type of lubricant was the main cause of decomposition, although it seemed inconceivable that moisture, pressure, and type of aspirin were not factors. Therefore, a factorial experiment was set up testing all combinations of lubricants at two levels, pressure at two levels, moisture at two levels, and two types of aspirin (10 per cent starch granulation and 40‐mesh crystal), the entire series being repeated for each of seven different lubricants. A total of 112 batches of tablets were prepared. The tablets were aged at 45° for four weeks and analyzed for salicylic acid content.
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