Abstract
1. Introduction Evidence supporting the roles played by phospho- lipase Az or phospholipase C and diglyceride-lipase in the release of arachidonic acid have been reviewed in [ 13. The precise mechanism, however, remains open to controversy. There is general agreement that throm- boxanes are formed from arachidonic acid released from the membrane phospholipids in thrombin-stim- ulated platelets. Furthermore, apparently selective phospholipase Az inhibitors such as mepacrine, bromophenacylbromide and CB 874 inhibit aggrega- tion in human, rabbit and guinea-pig platelets [2,3]. The exclusive action of these phospholipase Az inhib- itors nevertheless remains questionable since they act also as amphiphilic membrane-active agents [ 11. The release of arachidonic acid by the phospholipase C pathway is an alternative to the direct action of phos- pholipase Az and is supported by the apparent accu- mulation of diglycerides during platelet activation
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