Abstract
The Dorothy M. Davis Heart and Lung Research Institute (DHLRI) at the Ohio State University (OSU) in Columbus, Ohio, has evolved over the past decade to serve as a platform to translate discovery from the laboratory to new practices in the clinic. Governing concepts for this evolution have been focused mission, leadership and investigator accountability, cross-disciplinary collaboration, and ultimately patient-centered discovery. The DHLRI is one of the largest and most comprehensive Institutes/Centers at the OSU and among the largest freestanding Institutes in the country devoted to cardiovascular, pulmonary, renal, and metabolic disease. The DHLRI was born from the multidisciplinary, programmatic study of heart, lung, and kidney disease at OSU in the late 1990s. In 2000, the DHLRI opened the doors of its new freestanding home—one of the most advanced interdisciplinary facilities on the Ohio State campus (Figure A). In 2001, ≈40 DHLRI investigators published 114 manuscripts. Over the past 16 years, the DHLRI has expanded its scientific scope and research footprint across OSU. Beyond serving as the research arm of OSU Heart and Vascular Center (HVC), the DHLRI now serves >700 faculty, staff, and trainees and generated >600 manuscripts in 2016. In 2017, the DHLRI continues to strive to fulfill its overarching mission to develop innovative strategies to diagnose, prevent, and treat cardiovascular, pulmonary, renal, and metabolic diseases. Numerous core laboratories within the DHLRI offer innovative technologies to support all aspects of basic and clinical research. The clinical care provided nearby at the Richard M. Ross Heart Hospital and OSU Wexner Medical Center offers first-hand perspectives on how research is involved in the prevention, detection, and treatment of disease. Figure. The Dorothy M. Davis Heart and Lung Research Institute. A , Freestanding Institute serves as platform for translational discovery. B , The first demonstration of sinoatrial node exit block during parasympathetic …
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