Abstract
IT HAS BEEN FOUND (1) that the amount of andro gen excreted in the urine of normal adults varies from day to day when determined by the Zimmermann (2) reaction. This fluctuation is approximately ± 40% about a mean which is relatively constant for an individual, even over long periods of time. This finding has been recently confirmed (3). However, Callow (4) demonstrated that there is normally a nonspecific chromogenic fraction which gave a color value of about 6% of the total in a small number of urine specimens from several subjects. Talbot (5) confirmed this although he found a much higher value for this fraction in a number of instances. The question thus arises whether the daily fluctuation in total androgen output of the individual subject is accounted for by changes in the output of this nonspecific component or in the output of the specific 17-ketosteroids. Callow (4) has used the ratio of absorption coefficients with green and violet filters EG/EV, to determine whether an extract is relatively pur...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The Journal of Clinical Endocrinology & Metabolism
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
