Abstract
Background Prostaglandin (PG) D2 is substantially involved in allergic responses and signals via the seven-transmembranespanning/G protein-coupled receptors, chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) and D-type prostanoid (DP) receptor. While the proinflammatory function of CRTH2 is well recognized and CRTH2 is hence considered as an important emerging pharmacotherapeutic target, the role of the DP receptor in mediating the biological effects of PGD2 in allergic inflammation has remained unclear.
Highlights
The D-type prostanoid (DP) receptor enhances the signaling of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)
Prostaglandin (PG) D2 is substantially involved in allergic responses and signals via the seven-transmembranespanning/G protein-coupled receptors, chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) and D-type prostanoid (DP) receptor
Our data demonstrate the capacity of DP receptors to amplify the biological response to CRTH2 activation
Summary
The D-type prostanoid (DP) receptor enhances the signaling of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). Joint meeting with the Hungarian Society of Experimental and Clinical Pharmacology (MFT) Innsbruck, Austria. 29-30 September 2011
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