Abstract
Light and electron microscopic studies on foetal human fibroblast and glial cells infected with B. K. virus show a cytopathogenic effect similar to but not identical with that caused by polyoma and SV 40 viruses in murine and monkey cells, respectively. The first cytopathogenic effects appear at approximately 14 days and are complete at about 30 to 40 days. Light microscopy of unstained monolayers demonstrates roughening of the cell surface, liberation of exudate, cytoplasmic vacuolization and rounding of cells. Stained preparations show the same features and a series of nuclear changes consisting of light eosinophilic patches in the nucleoplasm, chromatin clumping and the development of a typical inclusion body. The nucleolus is not involved.
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