Abstract
The purpose of this study was to observe the cutaneous reactions of nicotinic acid (niacin)-furfuryl in various disease states and to carry out clinical experiments related to the mechanism or mechanisms involved. There is considerable evidence, as will be shown, that a thorough knowledge of this subject might lead to a better understanding of the pathogenesis of atopic dermatitis. The drug used in this study was the tetrahydrofurfuryl ester of nicotinic acid. Incorporated in an ointment it was first used as a rubefacient in inflammatory joint disease. If a small amount of 5% nicotinic acid furfuryl in a hydrous wool fat (lanolin)-petrolatum base<sup>*</sup>is rubbed in or simply laid on the skin of normal persons and allowed to remain for 20 to 30 minutes, over 95% react with the production of erythema with or without edema. The reaction is termed "typical." It is also noted in a large
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