Abstract
This study investigated whether there are differences in the composition of the cutaneous microbiome of the unaffected skin between patients with pressure ulcers compared with those without pressure ulcers. The cutaneous microbiome of the unaffected skin of 15 patients with sacral pressure ulcers compared to 15 patients without pressure ulcers was analysed. It demonstrated that the inter-individual variation in skin microbiota of patients with pressure ulcers was significantly higher (P = 0.01). The abundance of 23 species was significantly different with Staphylococcus aureus and unclassified Enterococcus the most abundant species in patients with pressure ulcers. Random Forest models showed that eight species were associated with pressure ulcers occurrence in 81% of the patients. A subset of four species gave the strongest interaction. The presence of unclassified Enterococcus had the highest association with pressure ulcer occurrence. This study is the first to demonstrate that the cutaneous microbiome is altered in patients with pressure ulcers.
Highlights
This study investigated whether there are differences in the composition of the cutaneous microbiome of the unaffected skin between patients with pressure ulcers compared with those without pressure ulcers
The cutaneous microbiome plays an important role in providing a healthy environment of the skin, and microbiome alterations influence host-microbe interactions leading to changes in host metabolism and immunity[9]
Maintaining a well-balanced cutaneous microbiome is essential in preventing the development of skin diseases
Summary
This study investigated whether there are differences in the composition of the cutaneous microbiome of the unaffected skin between patients with pressure ulcers compared with those without pressure ulcers. In view of the impact of skin bacteria on the development of skin disorders as highlighted above, cutaneous microbiota differences may significantly contribute to the risk of developing pressure ulcers. Such potential differences may offer a new way to identify patients at increased risk for pressure ulcers and can lead to new preventive measures based on modulation of the microbiota as well[7]. The aim of this study was to examine the cutaneous microbiome of the unaffected skin of hospitalized patients with and without sacral pressure ulcers
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