Abstract
The curse of the missing heritability
Highlights
Reviewed by: Gaurav Sablok, Istituto Agrario San Michele, Italy Zhixiang Lu, University of California, Los Angeles, USA Pavlos Pavlidis, Heidelberg Institute of Theoretical Studies, Germany
Bloom et al (2013) conducted a linkage analysis in a large yeast Saccharomyces cerevisiae cross with high statistical power to map functional quantitative trait loci (QTL) and found that most the additive genetic contribution can be explained by the detected QTL
It is striking that the “old-fashioned” linkage analysis can resolve the missing heritability problem arisen in the high-throughput genome-wide association study (GWAS) era
Summary
A commentary on Finding the sources of missing heritability in a yeast cross by Bloom, J. Bloom et al (2013) conducted a linkage analysis in a large yeast Saccharomyces cerevisiae cross with high statistical power to map functional quantitative trait loci (QTL) and found that most the additive genetic contribution can be explained by the detected QTL. It is striking that the “old-fashioned” linkage analysis can resolve the missing heritability problem arisen in the high-throughput genome-wide association study (GWAS) era.
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