The current status of drug resistance among common Cram-positive cocci in our hospital during the period of 2008 to 2008

Abstract

Objective To provide reference on logical antibiotic uses in the empirical treatment of infectious diseases bv analyzing the distribution of clinically isolated Gram-positive cocci and the current status of drug resistance. Methods Micrnbial strain identification and susceptibility testing were performed by using an automatic analyzer in the samples collected from different departments during the period of January 2008 to December 2009. Results The isolated Gram-positive cocci were mainly coagulase-negative staphylococci(154 strains, 12.3%), enterococcus(48 strains, 3.8%), staphylococcus aureus(612 strains, 49%), staphylococcus epidermidis(206 strains, 16. 5%), and staphylococcus haemolyticus(225 strains, 18%). The detection rate was 75.6% for coagulase-negative, methicillin-resistant staphylococcus and only 24.4% for methicillin-resistant staphylococcus aureus. Conclusions The resistance of several common Gram-positive cocci to antimicrobial drugs is rising. It is of importance to strengthen the detection of antibiotic resistance among pathogens in nosocomial infection for guiding the rational use of antimicrobial drugs and reducing the production of multi-drug resistant bacteria. Currently, vancomycin is still one of the most effective agents for nosocomial infection with Gram-positive cocci. The rate of vancomycin resistance and that of linezolid are lowest among staphylococcus aureus, while the rate of penicillin G. resistance is highest. Key words: Gram-positive cocci; Resistance