Abstract

Sunitinib malate is one of the multitargeted tyrosine kinase inhibitor, which are being used in clinic. It can inhibit more than 80 kinds of receptor’s tyrosine kinase, including epidermal growth factor receptor (EGFR), platelet-derived growth factor receptors, vascular endothelial growth factor receptors (VEGFR), etc. And tyrosine kinase inhibitor is involved in connection with the generation and progression of many kinds of cancer including lung cancer. Several studies have evaluated the effect of Sunitinib on non-small cell lung cancer (NSCLC), by single agent, continuous daily dosing or in combination with chemotherapeutics (with docetaxel or gemcitabine plus cisplatin), which all showed certain effect. The test of Sunitinib in combination with gemcitabine plus cisplatin for advanced NSCLC shown that at the maximum tolerated dose: oral Sunitinib 37.5 mg/day intermittently (Schedule 2/1: 2 weeks on treatment, 1 week off treatment) schedule with intravenous infusions of gemcitabine (1000 mg/m2 days 1, 8) and cisplatin (80 mg/m2 day 1), administered in 3-week cycles, 66.7% patients achieved partial responses. And adverse effects were mild to moderate in severity (grades 1 to 2). Therapy was generally well tolerated. In summary, all the evidence above suggests that Sunitinib may play an important role in the treating of NSCLC.

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