Abstract
Capillary Leak Syndrome (CLS) in patients with severe course of disease is more and more common, and the clinical manifestations of CLS include systemic edema, hypoproteinemia, effective circulating blood volume reduction and hemoconcentration. The common pathogenies are sepsis, severe trauma, cardiopulmonary bypass and so on. Clinically, CLS is usually divided into leakage period and recovery period, with different pathophysiologic process, clinical manifestation and treatment in different period respectively. Although there are more treatments, they are not effective treatment measures. There have been so many studies about improvement of endothelial function, macromolecular colloid liquid applications, and continuous blood purification treatment. Systematic understanding of the pathological mechanism, clinical manifestations and staging, diagnosis and treatment of the CLS has a guiding value.
Highlights
Capillary Leak Syndrome (CLS) is a syndrome of hypoproteinemia, hypovolemic shock, acute renal ischemia in clinical manifestations and the main reasons are the cell injury of capillary endothelial, increased vascular permeability, and a large number of plasma proteins leaking into the tissues of small molecule clearance
Patients in CLS will be with progressive systemic edema, hypoproteinemia, weight gain, blood concentration rapidly and be multiple organ failure in serious condition
Exclusion criteria: Critically ill patients are after fluid recover and confirmed by cardiac, hepatic, nephrogenic edema, neurogenic pulmonary edema, hemorrhagic and septic shock [3]
Summary
Capillary Leak Syndrome (CLS) is a syndrome of hypoproteinemia, hypovolemic shock, acute renal ischemia in clinical manifestations and the main reasons are the cell injury of capillary endothelial , increased vascular permeability, and a large number of plasma proteins leaking into the tissues of small molecule clearance. [1]. Patients in CLS will be with progressive systemic edema, hypoproteinemia, weight gain, blood concentration rapidly and be multiple organ failure in serious condition. Diagnostic criteria of CLS [2]: 1) Central venous pressure (CVP) decreases (
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