Abstract

Optimal postoperative analgesia has a significant impact on patient recovery and outcomes after cesarean delivery. Multimodal analgesia is the core principle for cesarean delivery and pain management. For a standard analgesic regimen, the use of long-acting neuraxial opioids (e.g., morphine) and adjunct drugs, such as scheduled acetaminophen and nonsteroidal anti-inflammatory drugs, is recommended unless contraindicated. Oral or intravenous opioids should be reserved for breakthrough pain. In addition to the aforementioned use of multimodal analgesia, preoperative evaluation is critical to individualize the analgesic regimen according to the patient requirements. Risk factors for severe postoperative pain or analgesia-related adverse effects will require modifications to the standard analgesic regimen (e.g., the use of ketamine, gabapentinoids, or regional anesthetic techniques). Further investigation is required to determine analgesic drugs or dose alterations based on preoperative predictions for patients at risk of severe pain. Outcomes beyond pain and analgesic use, such as functional recovery, should be determined to evaluate analgesic treatment protocols.

Highlights

  • Severe acute pain is a strong risk factor for postpartum depression and chronic pain [7, 8], which results in long-term psychological, social, and economic adversities [9, 10]. erefore, optimal pain control is a key priority on both humanitarian grounds and for efficient health service delivery [11,12,13]

  • Optimal pain control is a cornerstone of enhanced recovery after cesarean delivery (ERAC) [15, 16], and it is an essential component of the Obstetric Quality-ofRecovery (ObsQoR-10) score [17,18,19]

  • Regular Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and acetaminophen are recommended for enhanced recovery for cesarean delivery

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Summary

Identification of Women at Risk of Severe Postoperative Pain

Pain management protocols have moved toward a standardized approach to personalized analgesic management. In patients undergoing cesarean delivery, several studies have investigated the role of preoperative QSTs or pain response to local anesthetic infiltration in predicting acute postoperative pain [21]. The clinical use of the three simple questionnaires combined with the pain response to local anesthetic infiltration is easy to apply and may provide some value. Another approach is giving patients more of a role in analgesic regimen selection. Another study reported similar results, with patients choosing a higher dose (300 mcg intrathecal morphine + single dose oral gabapentin 600 mg) requiring more rescue opioids than those selecting a medium dose (150 mcg) or low dose (50 mcg) [27].

Special Concerns about Pain Control in Cesarean Delivery
Conclusion
In Conclusion
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