The curative effect analysis of cyproterone acetate combined with letrozole in the treatment of patients with polycystic ovary syndrome and infertility

Abstract

Objective To explore the clinical effect of cyproterone acetate combined with letrozole in the treatment of patients with ovulation disorder infertility caused by polycystic ovary syndrome (PCOS).Methods 124 patients with PCOS and infertility were selected and divided into three groups.Letrozole Group (42 cases) received cyproterone acetate combined with letrozole; Control Group (40 cases) received oral cyproterone acetate treatment; Clomiphene Group (42 cases) received oral cyproterone acetate combined with clomiphene.Record the sex hormone levels,cycle ovulation rate and pregnancy rate in three groups.Results The levels of T,LH,LH/FSH significantly reduced (P ＜ 0.01).In 42 ovulation induction cycles,35 cycles (87.5％) had advantaged follicle,34 cycles (85.0％) had ovulation,with 7 cases of pregnancy (17.5％).There were statistically significant differences in sex hormone levels,cycle ovulation rate,pregnancy rate between Letrozole Group and Control Group (P ＞ 0.05).E2 levels in ovulation phase and luteal phase and LH level in ovulation phase of Clomiphene Group were higher than those of Letrozole Group,without statistically significant differences (P ＞ 0.05).Conclusions Cyproterone acetate combined with letrozole in the treatment of patients with ovulation disorder infertility caused by polycystic ovary syndrome has good curative effect,can obtain same effect as clomiphene,offer one more choice for patients with ovulation disorder infertility caused by polycystic ovary syndrome. Key words: Polycystic ovary syndrome; Infertility; Letrozole; Cyproterone acetate; Clomiphene