Abstract
The synthesis of novel 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-ones is described including a one-step Mannich-type reaction followed by intramolecular ring closure of ethyl 3-methylpyridazine-4- carboxylate and aldimines, catalysed by the Lewis acid Cu(OTf)2 under microwave heating. This synthesis opens up possibilities to access this unexplored scaffold for medicinal chemistry.
Highlights
In the search for new biologically active compounds and drugs, extensive research is based on the synthesis of natural-like or small molecules
The synthesis of novel 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-ones is described including a one-step Mannich-type reaction followed by intramolecular ring closure of ethyl 3-methylpyridazine-4-carboxylate and aldimines, catalysed by the Lewis acid Cu(OTf)[2] under microwave heating
The synthesis started with the synthesis of ethyl 3-methylpyridazine-4-carboxylate 7 (Scheme 1)
Summary
In the search for new biologically active compounds and drugs, extensive research is based on the synthesis of natural-like or small molecules. Abstract The synthesis of novel 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-ones is described including a one-step Mannich-type reaction followed by intramolecular ring closure of ethyl 3-methylpyridazine-4-carboxylate and aldimines, catalysed by the Lewis acid Cu(OTf)[2] under microwave heating. The synthesis of 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-ones is reported, synthetized by a one-step Mannich-type reaction followed by ring closure of ethyl
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