Abstract
The PtII atom in the title complex, [Pt(C15H18N4O4S)(C2H6OS)], exists within a square-planar NS2O donor set provided by the N, S, O atoms of the di-anionic tridentate thio-semicarbazo ligand and a dimethyl sulfoxide S atom. The two chelate rings are coplanar, subtending a dihedral angle of 1.51 (7)°. The maximum deviation from an ideal square-planar geometry is seen in the five-membered chelate ring with an S-Pt-S bite angle of 96.45 (2)°. In the crystal, mol-ecules are linked via N-H⋯O, C-H⋯O, C-H⋯N and C-H⋯π inter-actions into two-dimensional networks lying parallel to the ab plane. The conformations of related cyclo-hexyl-hydrazine-1-carbo-thio-amide ligands are compared to that of the title compound.
Highlights
The PtII atom in the title complex, [Pt(C15H18N4O4S)(C2H6OS)], exists within a square-planar NS2O donor set provided by the N, S, O atoms of the di-anionic tridentate thiosemicarbazo ligand and a dimethyl sulfoxide S atom
The maximum deviation from an ideal square-planar geometry is seen in the fivemembered chelate ring with an S—Pt—S bite angle of 96.45 (2)
Molecules are linked via N—HÁ Á ÁO, C—HÁ Á ÁO, C—HÁ Á ÁN and C—HÁ Á Á interactions into two-dimensional networks lying parallel to the ab plane
Summary
Schiff base ligands and their complexes with transitional metals form an important functionality in medicinal, industrial and coordination chemistry (Hanifehpour et al, 2015; Singh et al, 2007). Work by medicinal chemists on the coordination and biological properties of metal complexes has contributed to the emergence of modern medicinal chemistry, which was inspired by the discovery of cisplatin. The thiosemicarbazone moiety containing Schiff base ligands chelated to platinum(II) shows high antitumor and anticancer activity; metal-based drugs are more promising and convenient as therapeutic agents (Nomiya et al, 1998; Kovala-Demertzi et al, 2003; Kovala-Demertzi et al, 2000; Anacona et al, 1999; Arafath et al, 2017b). The complexes of PtII with 4(N)-substituted derivatives of 2-acetylpyridine thiosemicarbazone exhibit potential antitumor, anticancer, antibacterial, antineoplastic and cytogenetic activities (Kovala-Demertzi et al, 1999, 2000, 2001). Carbazate containing N- and S-coordinating sites chelated to PtII exhibits potential antibacterial and anticancer activity (Tarafder et al, 2002; Arafath et al, 2019). E75, 1486–1489 research communications oxidobenzylidene-O]hydrazin-1-ylidene-N2}methanethiol}methanethiolato-S)(dimethyl sulfoxide-S)platinum(II), I
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