Abstract
Periplaneta americana L. is a Traditional Chinese Medicine that has been used in clinic treatment of various diseases for a long history. However, the therapeutic potential and the underlying mechanism of Periplaneta americana L. in the skin wound therapy was not investigated comprehensively yet. This study aims to investigate the influence of the crude ethanol extract of PAL in the different wound stages including: (1) the migration and chemotaxis to skin cells in the first stage; (2) proliferation and cells cycle of skin cells in the second stage; (3) remodeling effect and secretion of growth factors, collagens in the third stage; (4) as well as the influence in the blood vessels regeneration in the late stage. The crude ethanol extract of PAL was shown to (1) promote the keratinocytes proliferation and regulate the cells cycle of fibroblasts significantly; (2) stimulate the migration of keratinocytes and fibroblasts obviously; (3) enhance the EGF and VEGF secretion both in vitro & in vivo; (4) accelerate the wound healing, collagen synthesis and angiogenesis. The crude ethanol extract of KFX was shown a promising therapeutic agent for the wound therapy with great efficacy to accelerate the wound healing with improved quality.
Highlights
Skin trauma is a common and frequently-occurring disease caused by various injury factors
Cell cycle assay Cell cycle is a continuous process for the division of mother cells to daughter cells through the pathway of a series of events consisting of G0/G1, S, G2/M phase
Transwell assay We investigated whether Periplaneta americana L. (PAL) crude ethanol extract could affect the chemotactic motility of human skin fibroblasts (HSF) cells in vitro
Summary
Skin trauma is a common and frequently-occurring disease caused by various injury factors. Fast wound healing with skin appendages regeneration and less scar keep big challenges to be overcome in clinical practice. Wound repair mainly consists of three separate while overlapping stages, including: inflammatory response and cells migration, cells proliferation and remodeling with extracellular matrix, regeneration of skin appendages [2]. Challenges are Traditional Chinese Medicine (TCM) has been implemented for many diseases and is demonstrated by the high efficiency and safety for a long history in clinic. TCM at low cost has been widely practiced and is viewed as one of the alternatives for various wound treatment [5]. It is widely used in clinic in TCM to treat gastric ulcer and was shown for excellent effects [6], reminding its efficacy to stimulate healing and might be used as a
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