Abstract
Phospholipids are major membrane lipids that consist of lipid bilayers. This basic cellular structure acts as a barrier to protect the cell against various environmental insults and more importantly, enables multiple cellular processes to occur in subcellular compartments. Numerous studies have linked the complexity of membrane lipids to signal transductions, organelle functions, as well as physiological processes, and human diseases. Recently, crucial roles for membrane lipids in the aging process are beginning to emerge. In this study, we summarized current advances in our understanding of the relationship between membrane lipids and aging with an emphasis on phospholipid species. We surveyed how major phospholipid species change with age in different organisms and tissues, and some common patterns of membrane lipid change during aging were proposed. Further, the functions of different phospholipid molecules in regulating healthspan and lifespan, as well as their potential mechanisms of action, were also discussed.
Highlights
The relationship between lipids and aging has been well recognized
The association between membrane PLs and aging, and the regulation of the aging process and aging-related diseases by PLs have been greatly advanced in recent years
Identification of particular PL species that are associated with lifespan modulation has expanded our knowledge of how metabolic reprogramming affects aging
Summary
Reviewed by: Ales Tomcala, Academy of Sciences of the Czech Republic (ASCR), Czechia Andrew Carley, The Ohio State University, United States. Phospholipids are major membrane lipids that consist of lipid bilayers. This basic cellular structure acts as a barrier to protect the cell against various environmental insults and more importantly, enables multiple cellular processes to occur in subcellular compartments. Numerous studies have linked the complexity of membrane lipids to signal transductions, organelle functions, as well as physiological processes, and human diseases. Crucial roles for membrane lipids in the aging process are beginning to emerge. We summarized current advances in our understanding of the relationship between membrane lipids and aging with an emphasis on phospholipid species. We surveyed how major phospholipid species change with age in different organisms and tissues, and some common patterns of membrane lipid change during aging were proposed. The functions of different phospholipid molecules in regulating healthspan and lifespan, as well as their potential mechanisms of action, were discussed
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