The Cross-selectivity in Pd-catalyzed coupling of simple aryl C-H bonds

Abstract

Abstract Pd-catalyzed cross-couplings of C-H bonds have been pursued by researchers to produce unsymmetrical C-C bonds directly for over fifty years, which are currently prepared by Suzuki, Kumada, Stille, Neigishi, Heck, or Sonogashira coupling of C-halogen with C-M or C-H bonds. A big challenge is to obtain the high cross-selectivity of cross-coupling products, especially when the substrates have similar chemical C-H bonds, such as simple arenes. Lu and co-workers have studied Pd catalysis in the cross-couplings of aryl C-H bonds since 2003. This account introduces their strategy, understanding and research in cross-selectivity control, C-H activation mode, cross-coupling establishment and application in synthesis. 1 Introduction 2 Cross-selectivity Control 3 Conclusion