Abstract
In immunocytes from the mollusc Mytilus galloprovincialis, the major pathway followed by platelet-derived growth factor (PDGF)-AB and transforming growth factor (TGF)-β1 in provoking the release of norepinephrine, epinephrine and dopamine into cell-free hemolymph (serum) is mediated by a corticotropin-releasing hormone-adrenocorticotropin hormone (CRH-ACTH) biogenic amine axis. This axis not only annulled the inhibiting properties of PDGF-AB, it even reversed the latter's effect, while the inducing effect of TGF-β1 was amplified. These findings show that non-classical immune-neuroendocrine molecules, such as PDGF-AB and TGF-β1, are involved in building stress response, using the same conserved mechanisms present from invertebrates to vertebrates.
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