Abstract
The creation of synthetic crystalline bovine insulin.
Highlights
The creation of synthetic crystalline bovine insulinA great achievement in life science occurred in China—the complete synthesis of crystalline bovine insulin—which gave Chinese scientists a sense of great elation and pride
British molecular biologist Frederick Sanger determined the primary structure of insulin through 10 years of research: it comprises of two chains, chain A and chain B; chain A contains 21 amino acid residues while chain B consists of 30 residues; the two chains are linked by two disulfide bonds and there is an intra-chain disulfide bond in chain A (Fig. 2) (Sanger, 1959)
Driven by the “great leap forward” campaign in 1958, Shanghai Institute of Biochemistry, Chinese Academy of Sciences and Perking University proposed that China should artificially synthesize insulin and obtained the support of the Chinese government
Summary
A great achievement in life science occurred in China—the complete synthesis of crystalline bovine insulin—which gave Chinese scientists a sense of great elation and pride. British molecular biologist Frederick Sanger determined the primary structure of insulin through 10 years of research: it comprises of two chains, chain A and chain B; chain A contains 21 amino acid residues while chain B consists of 30 residues; the two chains are linked by two disulfide bonds and there is an intra-chain disulfide bond in chain A (Fig. 2) (Sanger, 1959) This is the first protein structure determined in human history, which Sanger was awarded the 1958 Nobel Prize in Chemistry for. You Wang’s group in Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences where they were to be responsible for the synthesis of chain A; Prof. Jingyi Niu of Shanghai Institute of Biochemistry, Chinese Academy of Sciences and his team would complete the synthesis of chain B; and Prof.
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