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Abstract
Experiments were staged for the evolvement of immunogical tolerance in adult rabbits with the aid of 6-mercaptopurine. After the administration of human serum albumin together with antimetabolite to rabbits, the animals formed no antibodies in response to subsequent albumin injection. This stage of tolerance continued for a period of not more than 4 months. In analogous experiments with human erythrocytes of the group IV blood group and with soluble antigens, isolated from the rat organs, no state of immunological tolerance was achieved, notwithstanding complete depression of antibody formation during primary administration of these antigens together with 6-mercaptopurine. In repeated administration of soluble antigens of rat organs, the antibodies evidently developed only to some of these antigens.
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