The covariant CDKN2A/B rs10811661 (C/T) gene polymorphism is associated with increased risk of type 2 diabetes mellitus in a Saudi Arabian population

Abstract

Background Genome-wide association studies have linked several single nucleotide polymorphisms with type 2 diabetes mellitus (T2DM). The present case–control study explored the probable association between the rs10811661 CDKN2A/B gene polymorphism and the risk of T2DM in a Saudi Arabian population. Patients and methods The study included 526 T2DM patients and 567 healthy control participants. The CDKN2A/B (rs10811661) polymorphism was genotyped using the TaqMan allelic discrimination method. Results The results identified single nucleotide polymorphism rs10811661 of CDKN2A/B as a risk factor for T2DM (odds ratio = 1.9; 95% confidence interval: 1.57–2.30; P= 0.0001). Levels of fasting plasma glucose and 2-h postprandial plasma glucose were significantly higher in patients with normal glucose tolerance but carrying the rs10811661 (C/T) risk allele compared with noncarriers. Conclusion A significant association was observed between CDKN2A/B rs10811661 (C/T) and susceptibility to T2DM in the Saudi Arabian population. Furthermore, the T allele is associated with an increased risk in patients with T2DM. The findings show that T2DM may interact with CDKN2A/B rs10811661 (C/T), which increases the risk of T2DM.