Abstract
In a study designed to investigate the effects of pregnancy and parturition on spontaneous lupus-like disease in NZB NZW mice, 24 female mice were allowed to breed repeatedly with male NZB NZW mice. Control female mice were caged separately without male mice. Seven months after the study began, the extent of autoimmune disease in parous and control animals was determined by assessing anti-DNA antinuclear antibodies, and the severity of renal lesions. Disease activity in both groups of mice was the same, indicating that pregnancy and parturition had no influence on autoantibody levels or severity of renal disease. It was concluded that bearing young had no effect on the course of autoimmune disease in NZB NZW mice.
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