Abstract
Constant-current coulometry has been applied to the titration of the allylic barbituric acid derivatives, sodium seconal and sodium sandoptal. Electrogenerated bromine was employed as the titrant and biamperometry was used to detect the endpoint. The effect of reaction time and excess bromine was evaluated, and optimum standard conditions were established. Quantitative bromination required an excess of bromine, hence a back-titration with standard arsenite was performed. Calibration curves were linear over the concentration range investigated, but changed slightly from day to day. The standard conditions were applied to the analysis of standard blood serum samples. Preliminary precipitation of protein was necessary, hence lower values than theoretical were obtained.
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