The cost-effectiveness of a program to reduce intrapartum and neonatal mortality in a referral hospital in Ghana.

Stephanie Bogdewic,Sebnem Ucer,Emmanuel K Srofenyoh,David M Goodman,Medge D Owen,Rohit Ramaswamy

doi:10.1371/journal.pone.0242170

Abstract

To evaluate the cost-effectiveness of a program intended to reduce intrapartum and neonatal mortality in Accra, Ghana. Quasi-experimental, time-sequence intervention, retrospective cost-effectiveness analysis. A program integrating leadership development, clinical skills and quality improvement training was piloted at the Greater Accra Regional Hospital from 2013 to 2016. The number of intrapartum and neonatal deaths prevented were estimated using the hospital's 2012 stillbirth and neonatal mortality rates as a steady-state assumption. The cost-effectiveness of the intervention was calculated as cost per disability-adjusted life year (DALY) averted. In order to test the assumptions included in this analysis, it was subjected to probabilistic and one-way sensitivity analyses. Incremental cost-effectiveness ratio (ICER), which measures the cost per disability-adjusted life-year averted by the intervention compared to status quo. From 2012 to 2016, there were 45,495 births at the Greater Accra Regional Hospital, of whom 5,734 were admitted to the newborn intensive care unit. The budget for the systems strengthening program was US $1,716,976. Based on program estimates, 307 (±82) neonatal deaths and 84 (±35) stillbirths were prevented, amounting to 12,342 DALYs averted. The systems strengthening intervention was found to be highly cost effective with an ICER of US $139 (±$44), an amount significantly lower than the established threshold of cost-effectiveness of the per capita gross domestic product, which averaged US $1,649 between 2012-2016. The results were found to be sensitive to the following parameters: DALYs averted, number of neonatal deaths, and number of stillbirths. An integrated approach to system strengthening in referral hospitals has the potential to reduce neonatal and intrapartum mortality in low resource settings and is likely to be cost-effective. Sustained change can be achieved by building organizational capacity through leadership and clinical training.

Highlights

Preventing neonatal death is a priority for national governments and the global health community
An integrated approach to system strengthening in referral hospitals has the potential to reduce neonatal and intrapartum mortality in low resource settings and is likely to be costeffective
In Ghana, neonatal mortality rate (NMR) was estimated at 25.3 deaths per 1,000 live births; while this number has decreased between 1990 and 2015 (-3.17) [1], the Ghanaian government estimates that neonatal deaths account for nearly 40% of deaths among children under the age of five [3]

Summary

Introduction

Preventing neonatal death is a priority for national governments and the global health community. In 2015, the global rate of neonatal deaths, defined as a death occurring within the first 27 days of an infant’s life, was 18.6 per 1,000 live births [1]. The neonatal mortality rate (NMR) remains significantly higher in SSA (27.8 deaths per 1,000 live births), compared to high-income countries (2.78) [1]. In Ghana, NMR was estimated at 25.3 deaths per 1,000 live births; while this number has decreased between 1990 and 2015 (-3.17) [1], the Ghanaian government estimates that neonatal deaths account for nearly 40% of deaths among children under the age of five [3]. More than 60 countries, accounting for 80% of neonatal deaths globally, will miss the Sustainable Development Goal (SDG) target of 12 neonatal deaths per 1,000 live births by 2030 [4]

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Conclusion