The correlative study of endothelial microparticles CD144+/Annexin V+ and coronary artery lesions

Abstract

Objective To investigate the relevance of levels of endothelial microparticles CD144+/AnnexinⅤ+ and the severity of coronary artery lesions. Methods One hundred and eighty-five patients underwent coronary angiography in the department of cardiology in our hospital. According to the angiographic findings, 2 groups were divided, such as the coronary artery lesion group and the normal control group. In the first group, there were 2 subgroups including acute coronary syndrome group (ACS), non-acute coronary syndrome group (non-ACS). Then, based on the Gensini score system, the coronary artery lesion group was divided into low score group (1.5-24) and high score group (>24). A flow cytometer detected the levels of plasma EMP-CD144+/Annexin Ⅴ+, cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, and uric acid for statistical analysis. Results Comparing with the normal control group, the coronary artery lesion group had high uric acid level (P 24) on Gensini score system, there was no significant difference in the level of EMP-CD144+/AnnexinⅤ+ and no linear correlation in the level of EMP-CD144+/Annexin Ⅴ+ (r = 0.088, P = 0.295). Conclusions Plasma levels of EMP-CD144+/Annexin Ⅴ+ does not correlate with the severity of coronary artery lesions, but it may impact on the stability of the coronary atheromatous plaque. Key words: Coronary heart disease; Endothelial microparticles; Severity of coronary artery lesions; Gensini score