The correlational research between G allele expression of matrix metalloproteinase 2 and complications after cardiac valve replacement

Abstract

Objective To investigate the relationship between G allele of matrix metalloproteinase 2 (MMP-2) and complications after cardiac valve replacement. Methods 187 patients who underwent heart valve replacement in our hospital from January 2015 to January 2018 were selected, all patients received anticoagulation therapy after operation, the complications were observed and the MMP-2 genotype was detected by gene sequencing. Results During the follow-up period, the incidence of complications was 28.88%; The proportion of MMP-2 gene GG + GC genotype in patients with complications was 62.96%, which was significantly higher than that in patients without complications (P<0.05); The international standardized ratio (INR) of patients with GG + GC genotype was (2.87±0.45), which was significantly higher than that of patients with CC genotype (P<0.05); The age and INR of the patients with complications were (57.01±6.79) years old and (2.70±0.65) years old, which were significantly higher than those of the patients without complications (P<0.05); Logistic regression analysis showed that INR value, age and MMP-2 gene GG+ GC type were risk factors for complications after cardiac valvle replacement [odds ratio (OR)=3.751, 3.013 and 2.440, P<0.05]. Conclusion The G allele of MMP-2 is a risk factor for complications after cardiac valve replacement, is worth further study. Key words: Matrix metalloproteinase 2; G allele; Cardiac valve replacement; Complications