The correlation of vitamin D with risk and severity of acute ischemic stroke

Abstract

Objective To analyze the correlation of vitamin D with risk factors and severity of ischemic stroke. Methods Between July 2018 and September 2018, 200 patients who were admitted to our hospital due to the acute ischemic stroke were included as subjects.The medical history and examination results of the patients were collected.Triglycerides(TG), total cholesterol(TC), high density lipoprotein(HDL)、low density lipoprotein(LDL) and other biochemical indicators were detected by Roche automatic biochemical analyzer.25 (OH) D levels were detected by Sorin automatic chemiluminescence analyzer.The severity of ischemic stroke was scored according to the National Institutes of Health Stroke Scale (NIHSS). Results The levels of TG, TC, LDL, and apoB were significantly higher in patients with 25 (OH) D deficiency than that of undeficient patients(P<0.05).25 (OH) D was negatively correlated with age, TG, TC, LDL, apoB, and NIHSS score (P<0.05). Acute ischemic stroke patients were divided into mild, moderate, and severe groups according to the NIHSS score. 25 (OH) D level was significantly different between patient groups with different disease severity(P<0.05). The risk of acute stroke increased gradually with the decrease of 25 (OH) D level.Low level of serum 25 (OH) D (<14.5ng/mL) increased the risk of acute stroke by more than 5 times (OR 5.57, 95%CI: 1.77-17.49, P<0.05) compared to that when serum 25(OH)D was higher than 23.65ng/mL. There results were obtained by taking into account of age, sex, other vascular risk factors. Conclusion Patients with acute ischemic stroke show significantly low levels of 25 (OH) D. Low level of 25 (OH) D can increase the risk and severity of ischemic stroke. Key words: Acute ischemic stroke; 25- hydroxyvitamin D; Risk; Severity