Abstract
Flavonoids and phenolics are compounds with hydroxyl groups (-OH) bound to aromatic rings which enable them to react with reactive oxygen species and eliminate free radical activity. Single bulb garlic ( Allium sativum var. solo garlic) is known to have antioxidant activity which comes from the phenolic groups. This study aims to determine the correlation of total flavonoid and phenolic levels with the antioxidant activity of ethanolic extracts from single bulb garlic grown in Magetan and Tawangmangu regions. This study included an observational analytic study with a cross-sectional design. Total flavonoid levels were measured by colorimetric method and total phenolic levels were measured by Folin-ciocalteu method using Spectrophotometric UV-Vis. Antioxidant activity was measured by DPPH method at a wavelength of 517 nm. The data analysis used was multiple linear regression. The results showed that the extract of single bulb garlic from Magetan had total flavonoids of 12,1833 ± 0,1943 mg QE/gram, total phenolics of 70,244 mg GAE/gram, and antioxidant activity with an IC 50 value of 20,216 ppm. The extract of single bulb garlic from Tawangmangu contained total flavonoids of 14,4833 ± 0,5911 mg QE/gram, total phenolics of 92,222 mg GAE/gram, and antioxidant activity with an IC 50 value of 13,777 ppm. The conclusion of this study is that there is a significant correlation of total flavonoid and total phenolic content with antioxidant activity.
Highlights
Flavonoids and phenolics are compounds with hydroxyl groups (-OH) bound to aromatic rings which enable them to react with reactive oxygen species and eliminate free radical activity
Jurnal Farmasi Sains dan Komunitas, 2019, 16(2), 96-103 metabolites and antioxidant activity is influenced by different growth sites where different growth places affect the environmental temperature and biochemical processes found in plants causing the content of secondary metabolites such as phenolic will be different (Sholekah, 2017)
The extract was identified as flavonoid because when it was added with Mg powder and HCl, it made bubble (H2 gas) and flavilium sodium until it changed into yellow
Summary
Flavonoids and phenolics are compounds with hydroxyl groups (-OH) bound to aromatic rings which enable them to react with reactive oxygen species and eliminate free radical activity. The extract of single bulb garlic from Tawangmangu contained total flavonoids of 14.4833 ± 0.5911 mg QE/gram, total phenolics of 92.222 mg GAE/gram, and antioxidant activity with an IC50 value of 13.777 ppm. Natural antioxidants can protect the garlic (Allium sativum var.solo garlic) body from free radical attacks and can slow because it has the main phytochemicals the occurrence of chronic diseases caused content of sulfur compounds, peptides, by an increase in reactive oxygen species steroids, terpenoids, flavonoids, and (ROS) especially hydroxyl radicals and superoxide radicals (Wahdaningsih et al, phenols (Agarwal, 1996). Based on the description above, a study investigating the correlation of total flavonoid and total phenolic content with the antioxidant activity of single bulb garlic ethanolic extract (Allium sativum var.solo garlic) is essential to carry out. Magetan and Tawangmangu area with considerations of the growing habitat temperature, soil pH, air humidity, and altitude of different places
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