Abstract
Background: Obesity is caused by several factors while sedentary lifestyle and excessive energy intake are the most important ones. Obesity could be due to abnormal calcium metabolism, and a high calcium intake may prevent obesity. Studying serum calcium level, albumin, and triglyceride concentrations, we searched for probable correlation between serum calcium level and anthropometric data of the participants.
 Materials and Methods: This cross-sectional study was performed in 2011 in Shiraz Endocrine and Metabolism Research Center on 468 participants. Anthropometrics and serum levels of calcium, albumin, and triglyceride levels were measured, recorded, and analyzed by SPSS statistical software.
 Results: 329 participants were female (70.3%) and the remaining were male (29.7%) with mean age of 46.08 ±15.22 years old. Corrected plasma concentration of calcium based on albumin level had a significant relation with weight, BMI, and triglyceride levels.
 Conclusion: It is assumed that obesity induces the production of inflammatory cytokines which stimulates bone absorption by osteoclasts that might subsequently lead to a higher serum calcium level in obese people who have a high level of triglyceride at the same time.
Highlights
Obesity, having a body mass index ≥ 30 kg/m2 is caused by several environmental factors such as sedentary life-style and excessive energy intake.[1,2] According to previous reports, obesity could be due to abnormal calcium metabolism, and a high calcium intake may prevent obesity.[3, 4] Intracellular calcium plays a key role in modulating the regulatory factors involved in hypertension, insulin resistance and obesity.[3]
In this study serum albumin and calcium levels were measured and serum level of ionized calcium was corrected according to serum albumin concentration; the mean ± SD level of the corrected calcium level was 9.88 ± 0.93 mmol
Data analyses showed that serum albumin level had a direct significant correlation with serum calcium level, weight and height of the participants; while it had a negative correlation with their age and abdominal circumference (P < 0.05) (Table 2)
Summary
Obesity, having a body mass index ≥ 30 kg/m2 is caused by several environmental factors such as sedentary life-style and excessive energy intake.[1,2] According to previous reports, obesity could be due to abnormal calcium metabolism, and a high calcium intake may prevent obesity.[3, 4] Intracellular calcium plays a key role in modulating the regulatory factors involved in hypertension, insulin resistance and obesity.[3]. PTH and 1, 25-hydroxy vitamin D levels are increased by low dietary calcium intake, which stimulates high levels of intracellular calcium in adipocytes. Obesity could be due to abnormal calcium metabolism, and a high calcium intake may prevent obesity. Albumin, and triglyceride concentrations, we searched for probable correlation between serum calcium level and anthropometric data of the participants. Anthropometrics and serum levels of calcium, albumin, and triglyceride levels were measured, recorded, and analyzed by SPSS statistical software. Conclusion: It is assumed that obesity induces the production of inflammatory cytokines which stimulates bone absorption by osteoclasts that might subsequently lead to a higher serum calcium level in obese people who have a high level of triglyceride at the same time.[GMJ. Conclusion: It is assumed that obesity induces the production of inflammatory cytokines which stimulates bone absorption by osteoclasts that might subsequently lead to a higher serum calcium level in obese people who have a high level of triglyceride at the same time.[GMJ. 2013;2(1):26-31]
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