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Abstract
ObjectiveNeutrophil-to-lymphocyte ratio (NLR) and red blood cell distribution width (RDW) reflect inflammation and these parameters have not been studied in patients with large cerebral artery infarction. This study investigated the correlation of these inflammation parameters with in-hospital mortality and length of hospital stay (LOS) in patients with large middle cerebral artery (MCA) infarction.Materials and methodsThe study was conducted with patients who had large MCA (M1 and M2 segments) infarction. Clinical data of the patients and laboratory results at presentation were obtained from our database and recorded for statistical analysis. Multivariate logistic regression analysis was used to investigate the prognostic factors. The correlation between hematological parameters and LOS was investigated using Spearman’s Rho and Pearson correlation tests.ResultsA total of 143 patients (48 patients with hospital mortality, 95 patients without hospital mortality) were included in the study. The median LOS in patients with hospital mortality [10 (2-90) days] was significantly higher compared to the patients without [7 (2-30) days] (p = 0.024). RDW-SD was found to be a poor prognostic factor according to the multivariate logistic regression model (p = 0.004). There was a significant but weak and positive correlation between LOS and NLR (p = 0.003, r: 0.248) and a significant but weak and negative correlation between LOS and eosinophil count (p = 0.001, r: -0.278).ConclusionsHigh RDW at presentation is a poor prognostic factor in terms of in-hospital mortality in patients with large MCA infarction. In addition, a positive correlation has been found between NLR and LOS.
Highlights
There are many factors that affect in-hospital mortality in patients with acute ischemic stroke (AIS) [1]
The median length of hospital stay (LOS) in patients with hospital mortality [10 (2-90) days] was significantly higher compared to the patients without [7 (2-30) days] (p = 0.024)
red blood cell distribution width (RDW)-SD was found to be a poor prognostic factor according to the multivariate logistic regression model (p = 0.004)
Summary
There are many factors that affect in-hospital mortality in patients with acute ischemic stroke (AIS) [1]. These include the patient’s age and severity of AIS, which are the strongest determinants of prognosis in the acute phase of stroke [2]. Previous studies have shown that LOS is associated with many factors such as hypertension, atrial fibrillation, smoking, ischemic heart disease, diabetes mellitus, severity of stroke, inpatient complications, subtype of stroke and age [4,5,6]. The correlation of routine hematological parameters with in-hospital mortality and LOS was not investigated in patients with large middle cerebral artery (MCA) infarction
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